macOS guide
Follow the steps in order to install uwu2x on macOS.
Getting uwu2x
Download uwu2x Pro 8.5 extension here. The downloaded file should be in the Downloads folder. Extract it, and open the resulting folder.
Enable PlayerDebugMode

Close After Effects and run this command in the Terminal (you can open it by searching "Terminal" in Spotlight Search) :
defaults write com.adobe.CSXS.12 PlayerDebugMode 1
I wrote CSXS.12 because I have After Effects CC 2025. It could be CSXS.14, CSXS.13, ..., CSXS.6 depending on your version. If you've already done this in the past, you can skip this step. We're typing these commands so the uwu2x Pro extension can open in After Effects. This is a known process, and you can find more information online if these short explanations were not detailed enough.Bypass Gatekeeper

You need to tell Gatekeeper to not delete uwu2x files. Gatekeeper may delete them because they are not signed. To do it, type this command :
xattr -cr uwu2x-pro
Move uwu2x-pro to extensions folder

Move the uwu2x-pro folder to “/Library/Application Support/Adobe/CEP/extensions” or “~/Library/Application Support/Adobe/CEP/extensions” if you are on a non-administrator session. If these paths do not exist, you can create one manually.
Create a render template

Make sure that you have a render template that outputs a video, like QuickTime format (or MP4 if you have AE 2024+). Follow this tutorial if you don’t know how to create one : https://youtu.be/X9ONcSdrL78. uwu2x will ask you to choose one.
Open uwu2x

Finally, start After Effects, and click on Window > Extensions > uwu2x Pro.
This page does not help ? Join the uwu2x Discord server to seek help >_<